M SERIES

Standard SIP Pilot-Industrial Solutions

The M series includes standard SIP fermenters/bioreactors available in a range of six different volumes from 30 up to 200 litres, with a wide range of options and accessories.

Features and Benefits:

  •  6 different volumes: 30 L, 50 L, 75 L, 100 L, 150 L, 200 L.
  • 3:1 H/D ratio.
  • Parts in contact with the culture AISI 316 L, other parts AISI 304.
  • Finishing: mirror polished (internal and external).
  • Compact design.
  • Double jacket (side/bottom), for higher heat transfer efficiency and optimal temperature control.
  • Bacteria (Toro sparger, Rushton impellers) and cell cultures (Sintered sparger, Marine impellers) configurations available.
  • Welded baffles.
  • Wide range of measurement and control options for cell cultures and aerobic/anaerobic microbial fermentations, including temperature, pH, dO​2​, dCO​2​, redox, antifoam, level, conductivity, weight, cell density (total cells, viable cells).
  • Modbus digital sensors.
  • Suitable for batch, fed-batch and continuous processes.
  • Stainless-steel industrial PCS ​LEM_2​, with a selectable number of peristaltic pumps, choosing between Watson Marlow WM 114, WM 313 and WM 520.
  • Powerful and accurate (1 RPM) brushless motor, mounted on top.
  • Different gas mixing strategies with a selectable number of TMFCs or solenoid valves, for air, O​2​, CO​2​ and N​2​.
  • SALAS (Solaris Sterile Liquid Addition System) included in the standard configuration.
  • Up to 2 steam bridges (re-sterilizable diaphragm valves for inoculum/feedings) can be added in option (with manual or automatic sterilization control).
  • Non-SIP sampling and harvest valves are included in the standard configuration. Steam SIP lines can be added in option. Manual or automatic sterilization.
  • TK connection.
  • Tri-Clamp stainless steel piping.
  • Single mechanical seal. Double mechanical seal, with automatic lubrication though steam condensate loop available in option.
  • Thermoregulation loop consisting of n.2 heat exchangers and recirculating pump.
  • Separate drains: cooling water return, condense drain to waste, hot condense return.
  • Gravimetric flow control (option): feed rates controlled through weight measurement.
  • CIP system options: n. of removable spray balls or integrated system (recirculating pump + n. of removable spray balls + software automation). N. of spray balls depending on vessel volume.
  • Optional vessel empty sterilization.

Automation and Software:

  • Innovative SCADA software​ LEONARDO​ ​3.0: a smart and user-friendly controller designed to provide a high level of automated management of the fermentation/cultivation processes.
  • 24” coloured touch screen industrial HMI.
  • Included in the equipment supply.
  • Data extraction in .csv format.
  • Remote access via PC, tablet or smartphone, with QR code scanning or dedicated portal.
  • Remote control for after sale assistance.
The M series can be equipped with

Accessories

CHILLER
The M series can be used for

Applications

Pilot scale process development

Scale up and scale-down studies

Production

in the following application fields:

Biotech

Pharma

Food & Beverage

Nutraceutical

Bio-Cosmeceutical

Biopolymers

Agriculture

Animal health & Nutrition

Probiotics

Biofuel

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