S - I SERIES

SIP and CIP Customisable Pilot and Industrial Scale Fermenters/ Bioreactors

The S and I series consist of highly automated pilot-industrial fermenters and bioreactors, available from 5 up to 30.000 litres and more (S series 5 – 200 L; I series 300 – 30.000 L).

These fermentation units are completely customisable, tailor-made starting from the clients’ specific requests.

Many options of measurement and control can be installed on the systems, as well as all the features of sterility and cleanliness, to satisfy even the most demanding criteria of the Pharma industry.

All vessels are designed, fabricated, inspected, documented, and tested in accordance with European PED or ASME.

Features and Benefits:

  • Top quality stainless steel with excellent finishing and high technology.
  • Insulated vessels, with the possibility of passivation.
  • Different H/D ratios.
  • Different types of finishing (mirror polish, scotch brite, electropolishing, etc.).
  • Different types of agitation (top-bottom, single or double mechanical seal with lubrication loop, magnetic stirrer).
  • Different types of thermoregulation loops (from basic to completely closed).
  • Microbial (aerobic, anaerobic) and cell cultures configurations available.
  • Suitable for batch, fed-batch and continuous processes.
  • Several gas mixing strategies with a selectable number of rotameters, TMFCs or solenoid valves, for air, O 2 , CO 2 and N 2.
  • Wide range of measurement and control options including temperature, pH, dO 2 , dCO 2 , redox, antifoam, level, conductivity, weight, cell density (total cells, viable cells), etc.
  • Modbus digital sensors.
  • Stainless-steel industrial PCS LEM_2, with a selectable number and type of peristaltic pumps.
  • cGMP certifiable.
  • Easy to access service lines, to easily perform maintenance.
  • The systems can be integrated with tanks (feeding tanks, mixing tanks, harvest tanks, etc.), CIP/SIP systems, centrifuges, filtration systems, and many more ancillary equipment.

Automation and Software:

  • Innovative SCADA software​ ​LEONARDO​ ​3.0​: a smart and user-friendly controller designed to provide a high level of automated management of the fermentation/cultivation processes.
  • 24” coloured touch screen industrial HMI.
  • Included in the equipment supply.
  • Data extraction in .csv format.
  • Remote access via PC, tablet or smartphone, with QR code scanning or dedicated portal.
  • Remote control for after sale assistance.
The S and I series can be used for

Applications

Pilot scale process development

Scale up and scale-down studies

Production

in the following application fields:

Biotech

Pharma

Food & Beverage

Nutraceutical

Bio-Cosmeceutical

Biopolymers

Agriculture

Chemical & Petrochemical

Bioremediation

General process plants

Animal health & Nutrition

Probiotics

Biofuel

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